| Abstract |
Nanostructured functional materials constitute one of the most dynamic and rapidly expanding fields in scienceand technology, which include their use in such diverse areas as materials technology, biotechnonology, energyand environmental technology, electronics, catalytic applications etc. From other side, the increasingly importantrole in biophysics and in life sciences is played by laser spectroscopie methods. The present project challengesone of the most exciting and phenomena rich sub-fields of nano-science and nano-technology (N&N): theinteraction of visible and near visible light with nanostructured materials. It is aimed at fabrication of optically-active synthetic nanostructures for the exploration of sensing mechanisms with biological matter.In the framework of the present project research activity is planned to be concentrated on, firstly, deliberatefabrication of optically-active substrate by means of state-of-the-art nanofabrication techniques (e-beamlithography, colloidal lithography etc.) and, secondly, exploration of obtained optically-active substrates forbiosensing applications. Utilizing shaped metallic nanostructures or arrays of metallic nanostrctures to influencethe fluorescence of biomolecules in close proximity to the surface is planned by tuning surface plasmonresonance energy of formed nanoarchitectures. Controlled positioning of macromolecular species on the pre-fomed nobel metal nanostructures to probe enhanced fluorescence or enhanced quenching, necessary for ultra-sensitive detection scheme, will be performed. Later goal constitutes a demostration of sensitivity of builtarchitectures to the binding events between preformed sensing platform and biomolecular species,complementary to those available in the fabricated synthetic bio-nanoarchitectures.Overall, the results of research activity are expected to contribute substantially in fundamental understanding ofsurface enhancement#
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