2-ADAMANTYL-4,6-DIAMINO-1,2-DIHYDRO-1-ARYL-1,3,5-TRIAZINE DERIVATIVES AS CELL PROLIFIRATION INHIBITORS

Patent Information
Patent
2-ADAMANTYL-4,6-DIAMINO-1,2-DIHYDRO-1-ARYL-1,3,5-TRIAZINE DERIVATIVES AS CELL PROLIFIRATION INHIBITORS
Abstract
A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(1-tricyclo[3.3.1.1<3,7>] decyl]-1,3,5-triazines where the aryl group is a subst ituted or unsubstituted phenyl, or naphthyl- group, as pharmaceutically accepted salts or as free bases.The phenyl group substituents are halides, alkyls, alkoxyls or nitro group. One or more of the above substituents are found one or more times each one, and in various positions of the phenyl group.The corresponding isomers, stereoisomers, enantiomers, free bases and their complexes with various natural macromolecules and synthetic derivatives of them.The invention refers to new and prototype compounds inhibiting the proliferation of unwanted cells that belong to pathogenic microorganisms, to human tissues, to pathological cells, or any pathological cell proliferation. It also refers to the synthesis and the method of synthesis of the above mentioned compounds.The synthesis and the method of synthesis thereof of a series characterized by the preparation of the final triazines, by cyclization of the bigouanide hydrochlorides with adamantane-1-carboxaldehyde. Preparation of the inclusion complexes is realized from compexation of the corresponding hydrochlorides of the above mentioned triazines with natural macromolecules or synthetic derivatives.
Patent Family
10944769
Authority
WO
Year Applied
2002
Year Granted
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NameSectorAbstractYear AppliedYear GrantedAuthority
2-ADAMANTYL-4,6-DIAMINO-1,2-DIHYDRO-1-ARYL-1,3,5-TRIAZINE DERIVATIVES AS CELL PROLIFERATION INHIBITORS

Health

2002_____EP
2-ADAMANTYL-4,6-DIAMINO-1,2-DIHYDRO-1-ARYL-1,3,5-TRIAZINE DERIVATIVES AS CELL PROLIFIRATION INHIBITORS

Health

A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(1-tricyclo[3.3.1.1<3,7>] decyl]-1,3,5-triazines where the aryl group is a subst ituted or unsubstituted phenyl, or naphthyl- group, as pharmaceutically accepted salts or as free bases.The phenyl group...
A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(1-tricyclo[3.3.1.1<3,7>] decyl]-1,3,5-triazines where the aryl group is a subst ituted or unsubstituted phenyl, or naphthyl- group, as pharmaceutically accepted salts or as free bases.The phenyl group substituents are halides, alkyls, alkoxyls or nitro group. One or more of the above substituents are found one or more times each one, and in various positions of the phenyl group.The corresponding isomers, stereoisomers, enantiomers, free bases and their complexes with various natural macromolecules and synthetic derivatives of them.The invention refers to new and prototype compounds inhibiting the proliferation of unwanted cells that belong to pathogenic microorganisms, to human tissues, to pathological cells, or any pathological cell proliferation. It also refers to the synthesis and the method of synthesis of the above mentioned compounds.The synthesis and the method of synthesis thereof of a series characterized by the preparation of the final triazines, by cyclization of the bigouanide hydrochlorides with adamantane-1-carboxaldehyde. Preparation of the inclusion complexes is realized from compexation of the corresponding hydrochlorides of the above mentioned triazines with natural macromolecules or synthetic derivatives.
2002_____WO
Series Of New 4,6-Diamino-1,2-Dihydro-1-Aryl-1,3,5-Triazines, Substituted By An Adamantyl Moiety In The Position 2 Of Triazine-Their Corresponding Salts, Isomers,Steroisomers, Enantiomers, Free Bases And The Complexes Of All The Above With Natural Macromolecules And Their Synthetic Derivatives.

Health

A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(-tricyclo[3.3.1.13,7]decyl]-1,3,5-triazines where the aryl group is a substituted or unsubstituted phenyl, or naphthyl-group, as pharmaceutically accepted salts or as free bases. The phenyl group substituents are...
A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(-tricyclo[3.3.1.13,7]decyl]-1,3,5-triazines where the aryl group is a substituted or unsubstituted phenyl, or naphthyl-group, as pharmaceutically accepted salts or as free bases. The phenyl group substituents are halides, alkyls, alkoxyls or nitro group. One or more of the above substituents are found one or more times each one, and in various positions of the phenyl group. The corresponding isomers, stereoisomers, enantiomers, free bases and their complexes with various natural macromolecules and synthetic derivatives of them. The invention refers to new and prototype compounds inhibiting the proliferation of unwanted cells that belong to pathogenic microorganisms, to human tissues, to pathological cells, or any pathological cell proliferation. It also refers to the synthesis and the method of synthesis of the above mentioned compounds. The synthesis and the method of synthesis thereof of a series characterized by the preparation of the final triazines, by cyclization of the bigouanide hydrochlorides with adamantane-1-carboxaldehyde. Preparation of the inclusion complexes is realized from compexation of the corresponding hydrochlorides of the above mentioned triazines with natural macromolecules or synthetic derivatives.
2002_____US
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